Optimizing the resveratrol fragments for novel in silico hepatocellular carcinoma de novo drug design
28 July 2024 , Scientific Reports vol.14, 17336
● Abstracts for Elementary School Students
Hepatocellular carcinoma (HCC) is a type of liver cancer. It happens more in some places because of things like hepatitis infections, drinking alcohol, and healthcare access. Some proteins help us understand how this cancer grows.
Scientists are studying a medicine called Fostamatinib for treating this cancer because it’s easy to use and has fewer side effects. Another substance, resveratrol, found in plants, might help prevent and treat many diseases, including cancer.In a study, scientists made a new version of resveratrol called FOR. They tested it with four proteins and found it worked best with one called VGFR3. This means FOR could be a good medicine for liver cancer in the future.
● Abstracts for Junior High School Students
Hepatocellular carcinoma (HCC) is a type of liver cancer that happens more in some places than others. This is because of things like hepatitis B and C infections, drinking alcohol, and how easy it is to get healthcare. Some proteins in our body are important for understanding how this cancer grows and spreads.
Scientists are looking at a medicine called Fostamatinib to treat this cancer because it’s easier for patients to use and has fewer side effects. Another substance called resveratrol, found in some plants, might help prevent and treat many diseases, including cancer, because it has good properties like being an antioxidant and anti-inflammatory. In a study, scientists made a new version of resveratrol called FOR, which works better and is safer. They tested it with four proteins and found that it worked best with one called VGFR3. This means FOR could be a good medicine for liver cancer in the future.
Optimizing the resveratrol fragments for novel in silico hepatocellular carcinoma de novo drug design doi:10.1038/s41598-024-68403-w
